Whole exome sequencing of adenoid cystic carcinoma
نویسندگان
چکیده
منابع مشابه
Whole Exome Sequencing of Lacrimal Gland Adenoid Cystic Carcinoma
Purpose To identify genomic mutations in lacrimal gland adenoid cystic carcinoma (LGACC) samples from patients. Methods Genomic DNA was extracted from LGACC specimens. Whole exome sequencing (exome-seq) was conducted to screen for mutations. Capillary sequencing was performed to verify mutations in genes shared by multiple samples. Luciferase assays were used to evaluate functional consequenc...
متن کاملCorrection: Whole-Genome Sequencing of Salivary Gland Adenoid Cystic Carcinoma.
Adenoid cystic carcinomas (ACC) of the salivary glands are challenging to understand, treat, and cure. To better understand the genetic alterations underlying the pathogenesis of these tumors, we performed comprehensive genome analyses of 25 fresh-frozen tumors, including whole-genome sequencing and expression and pathway analyses. In addition to the well-described MYB-NFIB fusion that was foun...
متن کاملPrimary cutaneous adenoid cystic carcinoma of shin
Primary cutaneous adenoid cystic carcinoma (PCACC) is a rare variant of adenoid cystic carcinoma (ACC) which originates from the skin adnexa, most probably eccrine and apocrine glands. This tumor has a head and neck predilection and also occurs in the chest, abdomen, back, and perineum. We hereby present a 63-year-old man with PCACC located on the shin. No previous similar case has been reporte...
متن کاملWhole Exome Sequencing for Mutation Screening in Hemophagocytic Lymphohistiocytosis
Background: Hemophagocytic lymphohistiocytosis (HLH) is an immune system disorder characterized by uncontrolled hyper-inflammation owing to hypercytokinemia from the activated but ineffective cytotoxic cells. Establishing a correct diagnosis for HLH patients due to the similarity of this disease with other conditions like malignant lymphoma and leukemia and similarity among its two forms is dif...
متن کاملWhole Exome Sequencing
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2013
ISSN: 0021-9738
DOI: 10.1172/jci67201